Isoniazid, Mechanism of action, Biological Activity, Resistance and Biotransformation

Document Type : Short Communication

Authors

1 Faculty of Pharmacy, Tanta university

2 Pharmacognosy department, Faculty of Pharmacy, Tanta university

3 Faculty of Pharmacy, Tanta University

Abstract

Isoniazid is a synthetic antimicrobial and one of the most essential first-line drugs used in the treatment of tuberculosis. In addition, isoniazid has been used as a prophylactic drug for patients with latent Mycobacterium tuberculosis infection to prevent reactivation of disease. It is a prodrug which activated by catalase peroxidase (KatG) enzyme. Catalase peroxidase enzyme converts isoniazid to reactive species. Isoniazid reactive species inhibit enoyl acyl-carrier protein reductase (InhA) enzyme which involved in the biosynthesis of fatty acids of mycobacteria. Isoniazid is metabolized by amidase enzyme into isonicotinic acid and hydrazine.
Chronic toxicity of isoniazid results in hepatotoxicity and peripheral neuropathy. For active tuberculosis, isoniazid is often used together with rifampicin, pyrazinamide and either streptomycin or ethambutol. Multiple, extensively and totally drug resistant strains of Mycobacterium tuberculosis were reported. Due to the development of Mycobacterium tuberculosis resistance to isoniazid, a continuous search for new drugs is a demand to combat this global problem.

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Journal of Advanced Medical and Pharmaceutical Research
Volume 4, Issue 2
September 2023
Pages 42-46

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