Soy protein is an important component of soybeans that has beneficial role in improving insulin resistance. Nuclear factor kappa B (NF-κB) is a crucial pathway that has been implicated in the development of metabolic syndrome. Our study aimed to examine the protective effect of soy protein isolate - as a natural NF-κB inhibitor - and its possible mechanism of action in amelioration of inflammatory and metabolic disorders induced in male albino rats by high fructose diet (10% w/v) via using synthetic NF-κB inhibitor (IMD-0354). Rats were randomized into normal control group, soy group, NF-κB inhibitor (IMD-0354) group, high fructose group, high fructose with soy group, high fructose with NF-κB inhibitor group, high fructose with soy and NF-κB inhibitor group. Serum glucose, serum insulin, serum free fatty acids, insulin resistance (HOMA-IR), NF-κB, phosphorylated insulin receptor (pISR), carbohydrate-responsive element-binding protein (ChREBP) were determined and histopathological examination of liver tissue was performed. The concurrent administration of IMD-0354 and/or soy protein with high fructose significantly increased pISR and decreased FFAs, NF-κB, glucose, insulin, HOMA-IR, and ChREBP as well as improved the pathological conditions of the livers. The metabolic and inflammatory disorders induced by chronic consumption of fructose could be inhibited by co-administration of soy protein through regulation of NF-κB signalling pathway.
El-Ashmawy, N., Khedr, E., Elbahrawy, H., & Abdelhamid, R. (2020). Preventive Role of Soy Protein in Fructose Induced Metabolic Dysfunction in Rats via Inhibition of Nuclear Factor kappa B Pathway. Journal of Advanced Medical and Pharmaceutical Research, 2(1), 8-15. doi: 10.21608/jampr.2020.47479.1009
MLA
Nahla El-Ashmawy; Eman Khedr; Hoda Elbahrawy; Reham Abdelhamid. "Preventive Role of Soy Protein in Fructose Induced Metabolic Dysfunction in Rats via Inhibition of Nuclear Factor kappa B Pathway". Journal of Advanced Medical and Pharmaceutical Research, 2, 1, 2020, 8-15. doi: 10.21608/jampr.2020.47479.1009
HARVARD
El-Ashmawy, N., Khedr, E., Elbahrawy, H., Abdelhamid, R. (2020). 'Preventive Role of Soy Protein in Fructose Induced Metabolic Dysfunction in Rats via Inhibition of Nuclear Factor kappa B Pathway', Journal of Advanced Medical and Pharmaceutical Research, 2(1), pp. 8-15. doi: 10.21608/jampr.2020.47479.1009
VANCOUVER
El-Ashmawy, N., Khedr, E., Elbahrawy, H., Abdelhamid, R. Preventive Role of Soy Protein in Fructose Induced Metabolic Dysfunction in Rats via Inhibition of Nuclear Factor kappa B Pathway. Journal of Advanced Medical and Pharmaceutical Research, 2020; 2(1): 8-15. doi: 10.21608/jampr.2020.47479.1009